Category: science kits

Friday, 1 February 2013

07:26 – Barbara spent last night at home. She’s spending tonight with her dad, and then her sister is covering Saturday and Sunday nights, with Barbara back on duty next Monday and Tuesday nights, if necessary. We’re hoping her mom will be back at home by next week.

I’m still working on science kits. We’re in pretty good shape right now, with roughly 40 kits in stock. I’m trying to get 60 more chemistry kits ready to assemble, followed by 60 more biology kits, followed by 60 life science kits.


08:24 – I’m off to sit in the den, watch Heartland re-runs, and label bottles. Thousands of them. Barbara usually does the bottle labeling on weekends while she watches stuff on Netflix streaming, but she’s been pretty busy with her parents lately so I’ll try to take up some of the slack.

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Wednesday, 30 January 2013

08:39 – Barbara just headed off to work. This evening, she’s meeting a friend for dinner and then spending the night with her dad. Her mom is doing much better. They have her on IV antibiotics for a lung infection, but I’d be surprised if they release her sooner than this weekend.

As usual, winter in Winston-Salem is a mixed bag. After an ice storm last Friday followed by several days of lows well below freezing and highs not much if at all above freezing, yesterday’s high on our recording thermometer was 76F (24C). It was 61F (16C) at 0645 this morning, and the forecasters say we’ll have strong thunderstorms and possibly tornadoes this afternoon and evening. Then the temperature starts dropping again, with lows the rest of the week well below freezing.

I’m still working, gradually, on getting my lab cleaned up. For the first time in a long time, I have visible evidence that the countertops are beige. I’m also working on the LK01 Life Science Kit, which we intend to start shipping in March.


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Tuesday, 29 January 2013

08:41 – The cops never, ever stop looking for a cop killer. In October, 1996, a local cop, Gregory Martin, radioed in that he was making a traffic stop and requested backup. A state cop soon arrived at the scene and found Martin dead on the ground by the side of the road and no one else in sight. The morning paper says three suspects are now in custody and have been charged with first-degree murder. If they’re guilty, I hope they’re executed. Anyone stupid enough to kill a cop is too stupid to live anyway.

Barbara spent the night with her dad, and is going straight into work from there. No word yet on when her mom will be released from the hospital. Sankie is suffering from sleep deprivation and hunger. No surprise, since she hasn’t been able to sleep or eat since Dutch came home from the hospital last time. There may also be other things going on, including possibly pneumonia and a UTI. Barbara said she may be released tomorrow, but I’d be surprised. Barbara and Frances are looking into getting someone to sit with Dutch and Sankie on a temporary basis, but unless/until that happens it looks like they’ll be taking turns staying over at her parents’ apartment themselves.

Last night, Colin and I played ball and finished series four of Heartland. Barbara is home tonight, unless something changes, but will probably being staying with her dad tomorrow night. If so, Colin and I will start on series five of Heartland. Series six is running now on CBC, and I’m bittorrenting HD versions of the episodes as they air. (I keep my upload speed throttled to 0.0 KB/s, so I’m breaking no laws by downloading them; I’m not “making available” by uploading.)

The HD episodes are about 1.4 GB each, and are typically in .mkv format. The old version of DeVeDe that I use to create video DVDs doesn’t work properly with .mkv files, so I run the .mkv files through ffmpeg to convert them to mpegs, which DeVeDe handles well. I end up with six DVDs per season, three episodes per DVD. Only the first 12 episodes of series six have aired, with the final six to be aired in February and March. The good news is that series six is getting higher ratings than series five did, so there should be a series seven.

We continue to build science kits. Right now, I’m working on the new LK01 Life Science Kit.


08:59 – Barbara just sent me this video of a Border Collie trying to force an uncooperative horse to do what it’s told. Boy, does this look familiar. I see it every time I walk Colin. The only difference is that on those walks I’m the horse.


10:21 – One of the good things about my lab is that I have lots and lots of glassware and plasticware. Hundreds of individual items: beakers, graduated cylinders, volumetric flasks, funnels, stirring rods, and on and on. That means I almost always have a clean whatever-I-need. But one of the bad things about my lab is that I have all that stuff. When I use a vessel, I just rinse it and put it in the sink to be washed later. The problem is, later never comes until I have piles of stuff in the sink and covering all the counters on both sides and usually the floor, by which time cleaning up my lab becomes an Augean Stable thing. The other day, Barbara was cleaning downstairs and was about to step into my lab. She flipped the lights on, immediately flipped them back off, and just turned around and walked away.

So yesterday I decided I’d better get started on cleaning up my lab. It’ll take a while because I’m going to do it gradually. I couldn’t get to the sink in the lab, so I filled a 10-gallon (40 liter) bin with dirty glass/plasticware and carried it upstairs to the kitchen to wash it there. (Most of the stuff was already reasonably clean, so there’s no real hazard to washing it upstairs.)

The goal is to get the floor, counters, and sink in the lab completely empty and clean. That’s going to take some doing. I decided this task needed a name of its own, so I’m calling it Operation Overlord.

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Sunday, 27 January 2013

08:22 – The hospital admitted Barbara’s mom yesterday. They checked her dad, who’d also fallen, and sent him home. Dutch was afraid to stay by himself, so Frances stayed with him while Barbara made a flying visit home to pick up clothes and whatever else she needed to stay the night with her dad. I suspect she’ll have to stay with her dad tonight as well, and possibly every night until her mom is released from the hospital.


09:34 – Yesterday we shipped a biology kit and a chemistry kit, the last two kits we’ll ship under the old postage rates. We ship most of our kits in USPS Regional Rate B boxes, with the smaller kits shipping in RR A boxes. Kits that ordinarily ship in RR B boxes but are going to zone 8 ship in large flat-rate boxes because they cost a buck or so less to ship than the RR B boxes. The cost to ship large flat-rate boxes increased 4.4%, from $14.65 to $15.30. Before the postage increase, our cost to ship RR B boxes ranged from $5.90 for nearby addresses up to $12.74 for zone 7 addresses. It’s now $6.16 for nearby addresses up to $13.25 to zone 7. Even with increases in the 4% to 5% range, USPS is still the best shipping option for us, by far.

Even with everything else that’s been going on, we’re in good shape for now in terms of finished-goods kit inventory. We have between three and four dozen finished kits on hand. The problem is, the well has gone dry. We assembled those finished kits from subassemblies already in stock. To build more, we first need to build more subassemblies, which means we need to label and fill a bunch of bottles. That’s the time-consuming part, but we’ll get it done before we run out of kits.


12:34 – As of now, we’re no longer shipping our science kits to Canada. Part of the reason for our decision was the paperwork hassles, but it had more to do with shipping costs. We’ve had a lot of email from Canadians who were outraged by the $40 surcharge on shipping kits to Canada. Well, as of today, that surcharge would have gone from $40 to $54. Probably fewer than 25% of our Canadian customers had us ship the kits to Canada. Most Canadians live reasonably close to the US border, and many of them frequently visit friends or family in the US. They have us ship the kits to a US address and then just drive back over the border into Canada with their kits. No one has ever reported a problem with doing so. I’m sorry to disappoint potential customers who live too far from the US border to make a trip to the US convenient, but it just no longer makes sense for us to continue shipping kits to Canada.

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Saturday, 26 January 2013

10:32 – I’m doing laundry while Barbara continues to clean and organized the finished area in the basement. When she finishes down there she’ll start labeling bottles. She has to go over to her parents’ house to meet a real estate agent mid-afternoon, but otherwise we’re in for the weekend. The roads and sidewalks are still covered with ice. Fortunately, it’s to warm up enough today to melt off some of the accumulation.

I’m still organizing and counting our raw materials inventory for the science kits. We’re in good shape on most stuff and great shape on some. Both to minimize working capital and storage requirements, I try to maintain raw materials inventory at pretty low levels on stuff that’s easy to get and has multiple sources. On the other hand, I try to maintain pretty high levels of stuff that’s frequently back-ordered, particularly if it’s inexpensive and/or available from only one source. For example, we have only one reasonable source for the 5/10/15X pocket magnifiers we use in the biology, forensics, and life science kits. I ordered 300 of those last week. They arrived yesterday. I can order those, if necessary, from another of my wholesalers, but at a cost about 75% higher. Same deal on alligator clip leads. I can buy those nearly anywhere, but one of my suppliers sells them at about 60% the price other suppliers charge. (They’re exactly the same product…) So I ordered 500 each of the black and red leads, which also arrived yesterday. It’s worse for a few items that are single-source. For example, the exact stainless-steel spatula that we use in all of our kits is available from only one source, and they’re sometimes backordered. Without those, we can’t build kits. The things cost us something like a buck each, plus shipping. We’re down to low inventory on that spatula, so I’m going to order 500 next week and up the re-order quantity to 200 on that item. I don’t mind devoting $200 to $500 in working capital to an item that’s a showstopper.


13:23 – Barbara was in the shower about 11:30 when her sister called to tell her that their mom had fallen and had some cuts and scrapes. Tom, the guy from the retirement village, was in their apartment with them. He said it didn’t look too bad, but Barbara’s mom wanted to call 911. So Tom called, expecting that they’d just patch her up and leave. Instead, the EMTs transported her to the hospital. I guess at her age the fact that she hit her head (her face, actually) was enough for the EMTs to decide she’d better be seen by the doctors. They took Dutch along, too, because he fell while he was trying to help Sankie get up. Barbara called a little while ago from the hospital. They don’t know yet if Sankie will be admitted or sent home. I hope the former, because I think she needs to be under observation at least overnight, if not longer.

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Friday, 25 January 2013

07:32 – The weather forecasters say we have a 70% chance of a blizzard today. Snow, sleet, and freezing rain, with accumulations expected to reach a quarter to half an inch (6.35 to 12.7 mm), mostly ice. It’s to start coming down this afternoon and continue through the evening. Schools are letting out early. The high today is to be below freezing, so tomorrow morning is likely to be a mess. At least the brine trucks have been out. They worked all day yesterday. The streets in our neighborhood and presumably the rest of the city are all covered with parallel white streaks of salt.

I’ve been organizing and counting our raw materials inventory for the science kits. As of now, we have most of what we need for another 150 or so kits. With finished-goods inventory we already have on hand, that should be enough to carry us through April or so. I’ll place some small orders soon to fill out the inventory and maybe boost it to 200 kits’ worth, and wait until closer to summer to place the larger orders to prepare for the autumn rush.


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Wednesday, 23 January 2013

07:42 – I told Barbara last night that she shouldn’t worry about Colin and me at home. We can hold down the fort here if she wants to spend more time with her dad over the coming days, weeks, and possibly months. Today, she’s picking up her parents to drive them over to an audiologist appointment in High Point. They need to visit the audiologist regularly to get their hearing aids cleaned and checked. Her dad said he needed to keep this appointment. If Dutch is up to it, they may stop for dinner on the way home. If not, Barbara may have dinner with them at the retirement village. She’ll either bring me something for dinner or I’ll just make something for myself.

Work on science kits continues. Sales have slowed down a lot since the first half of this month, but we’re still doing well. So far this month, we’ve already sold more kits than we did in January, February, March, and April of 2012 combined. On that basis, I’m expecting things to really start getting busy starting in July. Between now and then, we’ll focus on getting chemical bottles ready, which is the real labor-intensive part. We can build kits pretty quickly on-the-fly if we don’t have to spend time labeling and filling bottles. With only a couple of exceptions, the chemicals we provide in the kits are stable indefinitely, which means we can make them up weeks to months ahead of time.


09:22 – Like “unionized”, “elegant” is a word that chemists use differently from most people. To a chemist, elegant means simple, with nothing wasted. I came across an excellent example of an elegant synthesis while reading Derek Lowe’s blog last week and checking one of the drugs he mentioned on Wikipedia. It’s metformin, a drug used to treat Type 2 diabetes.

“According to the procedure described in the 1975 Aron patent, and the Pharmaceutical Manufacturing Encyclopedia, equimolar amounts of dimethylamine and 2-cyanoguanidine are dissolved in toluene with cooling to make a concentrated solution, and an equimolar amount of hydrogen chloride is slowly added. The mixture begins to boil on its own, and after cooling, metformin hydrochloride precipitates with a 96% yield.”

Wow. That is truly elegant. Simple, and nothing wasted. A 96%(!) yield, and the stuff just falls out of solution. That’s a synthesis that will warm the cockles of the heart of any synthetic chemist, let alone the chemical engineer who’s responsible for upscaling a laboratory-level synthesis to an industrial-level synthesis.

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Sunday, 20 January 2013

08:23 – Among all the regular weekend tasks yesterday, Barbara spent a few hours doing kit stuff, including building 48 small-parts bags for chemistry kits and labeling a bunch of bottles. I timed her, and found she can label 300 bottles/hour. That translates to about nine hours’ work for her to label containers for 60 chemistry kits. Both of us working together should be able to fill, cap, and seal those 60 kits worth of containers in another nine to 12 hours.

Of course, there’s a lot more to building kits than just labeling and filling containers and building small-parts bags. Everything from making up chemicals to figuring out what needs to be ordered and ordering it to receiving and shelving orders as they arrive to taping up boxes for the kits to assembling the kits to processing orders and printing postage labels. Still, at this point, I estimate that if Barbara and I were both working full-time on kits we could produce 50 to 60 kits a week. Call it 2,500 to 3,000 kits a year. Even if she continues to work full-time and helps me on the weekends, some evenings, and an occasional vacation day, we should be able to crank out at least 20 kits a week or 1,000/year. That’ll do for now.


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Saturday, 19 January 2013

10:59 – This morning, I’m doing laundry and my other usual Saturday tasks while Barbara continues with her annual Deep Clean. She’s working downstairs this morning. This afternoon and tomorrow we’ll do kit stuff. She’s off work Monday for the holiday, but has commitments for most of that day. Right now, she’s building 48 small parts bags for the chemistry kits.

During the relatively slow period through the end of April, I want to focus our kit efforts on getting as much as possible of the labor-intensive stuff complete to make it possible to knock out finished kits quickly during the summer and autumn rush. That’s mostly labeling and filling containers. So, after we finish building all of the kits we can with what’s currently in stock, the next step is to label and fill 60 sets of chemistry kit containers, followed by 30 sets each of biology kit and forensic science kit containers. That gives us some breathing room, which we’ll use to label (but not fill) more sets of containers. In addition to finished goods inventory, I’d like to start July with at least 300 labeled container sets for the chemistry kits, 150 for biology kits, and 90 for forensic science kits, with at least half of them filled.


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Friday, 18 January 2013

08:07 – We got what looks like a couple inches (~ 5 cm) of wet snow through about midnight, followed by rain and freezing rain. The temperature is now hovering right around freezing, which is going to make Barbara’s morning commute a mess. Colin is enjoying the snow. He’s never seen much of it.

Even with everything else going on, we’re managing to keep up with the demand for science kits. All of the kits are in stock, and we’re building more as fast as we can. The problem is, this is supposed to be a slow time of year, and I’d planned to spend this slow period doing things like pre-labeling thousands of bottles and otherwise preparing for the rush. Our goal for this year is 500 kits, but at the current run rate we’re doing close to that now on an annualized basis, not taking seasonality into account. Factoring in seasonality, if our current run rate holds up, we’d easily do 1,000 kits this year–our goal for CY 2014–and we might do 2,000. That’s why I’m kind of hoping that this mini-rush is an anomaly. If it isn’t, we’re going to be covered up all year long.


11:28 – I certainly don’t always agree with Ambrose Evans-Pritchard–he’s much too Keynesian for my taste–but his articles and blog entries are usually worth reading. Here’s an interesting one: A new Gold Standard is being born

I agree with him that returning to the Gold Standard is a bad idea, but not for the reasons he thinks. He favors fiat currency because he wants governments and central banks to be able to fiddle with the money supply. I don’t. I’ve always been a hard-money guy. Giving any government the ability to create “money” out of nothing always, without exception, ends badly. And, as he points out, central banks and governments are fully aware that the value of the Big Four fiat currencies–the US dollar, the euro, the GB pound, and the Japanese yen–are going to have their value inflated away big-time. No one wants to hold any of them, given a choice. The dollar is still by far the best of the four, and it’s pathetic. Gold and other commodities can’t be inflated.

But gold is a very poor choice of a value store, for two reasons. First, there’s not enough of it. At $2,000 per troy ounce, a kilogram of gold is worth only about $64,000. A tonne (1,000 kilos) of gold is worth only $64 million, and a kilotonne (1,000,000 kilos) only $64 billion. The other, and more important, reason is that a value store should be valuable because of what you can do with it, not merely because it’s rare (in an economic sense). Gold does have many practical uses, but certainly none that require it by the multi-kilotonne.

I would like to see the US dollar become a hard currency again, as it hasn’t been since 1964 (or 1970, depending on how you look at it). But returning to the Gold Standard isn’t the way to do it. Instead, the federal government needs to remonetize our currency by holding a defined basket of commodities for each dollar issued. The value of a dollar might be defined as a combination of so many milligrams of gold, so many milligrams of copper, so many grams of wheat, so many grams of petroleum, and so on. The actual value of those commodities will fluctuate with market conditions, but having the basket contain 100 or 1,000 different commodities minimizes the effects of such fluctuations and would keep the value of the dollar stable. But the key issue is that the government must actually hold the required commodities in the required amounts for each dollar it issues, and must redeem those dollars on demand by accepting a dollar and handing the depositor that market-basket mix.

Of course, you wouldn’t be able to walk into a bank, hand them a dollar bill (or even a $1,000,000 bill) and expect them to cough up the appropriate amounts of 100 or 1,000 different commodities. But the market would take care of that. You would be able to hand over $1,000 or $1,000,000 and receive the appropriate commodity or mix of commodities in the amounts that reflected the current market prices of those commodities.

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